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New controlled release systems produced by self-assembly of biopolymers and colloidal particles at fluid-fluid interfaces
Partial coalescence in emulsions is a destabilization mechanism whereby the droplets retain their individual identity but there is a molecular contact between their content. This process can occur under fluctuating temperatures and/or shear stress, which effects the stability and quality of emulsions. In the case of topical drug delivery systems, in particular supersaturated oil-in-water (o/w) creams, the molecular exchange of dissolved drug from one droplet to the other is a critical issue because it can induce drug crystallization and enhance crystal growth. In this work two approaches to address the problem are reported: the stability of the emulsion in relation to (i) shear exposure and (ii) temperature cycling. Some ideas on how this approach can be used to identify critical process parameters and predict long term stability of supersaturated emulsions are discussed. (C) 2007 Elsevier B.V. All rights reserved. [hide]
Scientific Board
Andreas Bausch
TU Munich, Germany ►
Peter Fischer
ETH Zurich, Switzerland ►
Anne-Marie Hermansson
SIK, Sweden ►
Martin Kroger
ETH Zurich, Germany/Switzerland ►
Erik van der Linden
Wageningen UR, The Netherlands ►
Niklas Loren
SIK, Sweden ►
Leonard Sagis
Wageningen UR, The Netherlands ►
Erich Windhab
ETH Zurich, Switzerland ►
Klaas-Jan Zuidam
Unilever, The Netherlands ►
Scientific Stuff
Manuela Duxenneuner
ETH Zurich, Switzerland ►
Sophia Fransson
SIK, Sweden ►
Nam-Phuong Humblet-Hua
Wageningen UR, The Netherlands ►
Joeska Husny
ETH Zurich, Australia/Switzerland ►
Orit Peleg
ETH Zurich, Israel/Switzerland ►
Cyrille Vezy
TU Munich, Germany ►
Varvara Mitropoulos
ETH Zurich, Switzerland ►
Associated Scientists
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Enjoy your reading
SY Tee, AR Bausch, PA Janmey,
The mechanical cell
CURRENT BIOLOGY 19 (2009) R745 ►Selected conferences (co-)organized by project members
8th World Congress on Computational Mechanics WCCM8 2008
30 June - 5 July 2007, Venice, Italy ►15 May 2025
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